Abstract: Objective: To investigate the effects of recombinant human growth hormone (rhGH) on body height and blood lipid of children with growth hormone deficiency (GHD) and idiopathic short stature (ISS). Methods: 37 children with GHD and 35 children with ISS were all treated with rhGH subcutaneous injection regularly. All the children were followed up every 3 months for 12 months, body height and blood lipid were measured during follow-up. Results: After treatment, the body height of GHD children and ISS children were all significantly higher than that before treatment (P<0.05). After treatment, the total cholesterol and triglyceride of GHD children and ISS children after treatment had no significant differences compared with that before treatment (P>0.05). After treatment, the high-density lipoprotein of GHD children and ISS children were significantly higher than that before treatment, while the low-density lipoprotein were significantly lower (P<0.05). Conclusions: rhGH treatment can significantly improve the body height and blood lipid indexes of GHD and ISS children, so it is worthy of clinical application.

Key words: Recombinant human growth hormone (rhGH), Growth hormone deficiency (GHD), Idiopathic short stature (ISS), Body height, Blood lipid

摘要： 目的:探讨重组人生长激素（rhGH）对生长激素缺乏症（GHD）和特发性矮小（ISS）患儿身高和血脂指标的影响。方法:选取37例GHD患儿和35例ISS患儿,均给予rhGH皮下注射规律治疗,每3个月随诊一次,随诊时测量患儿身高、检测血脂指标,共随诊12个月。结果:治疗后,GHD患儿和ISS患儿的身高均明显高于治疗前,治疗前后比较差异有统计学意义（P<0.05）。GHD患儿和ISS患儿,治疗后总胆固醇（TCH）、甘油三酯（TG）与治疗前比较,差异无统计学意义（P>0.05）;两种患儿治疗后的高密度脂蛋白胆固醇（HDL-C）明显高于治疗前,低密度脂蛋白胆固醇（LDL-C）明显低于治疗前（P<0.05）。结论:rhGH治疗可明显改善GHD、ISS患儿的身高及血脂指标,值得临床应用。

关键词: 重组人生长激素（rhGH）, 生长激素缺乏症（GHD）, 特发性矮小（ISS）, 身高, 血脂