Abstract: Objective To compare and analyze the effects of "double-microporous" three-port and traditional three-port thoracoscopic lobectomy on the levels of serum inflammatory factors in lung cancer patients. Methods A total of 80 lung cancer patients treated between January 2021 and January 2024 were retrospective collected and divided into the study group (n=41) and the control group (n=39) based on different surgical methods. The former underwent double microporous three hole thoracoscopic lobectomy, while the latter underwent traditional three hole thoracoscopic lobectomy. The surgical indicators and complications were compared between the two groups, as well as the lung function (maximum ventilation per minute, maximum expiratory flow), biochemical indicators (CYFRA21-1, LCN2, CA125), inflammatory factors (IL-6, IL-2R, IFN - γ) before and after surgery. Results Compared with the control group, the study group had a shorter chest tube placement time, hospitalization time, incision length, and operation time, and less blood loss and postoperative drainage (P<0.05). Compared with the control group, one week after surgery, the study group had higher maximum minute ventilation and maximum expiratory flow, and lower serum CYFRA21-1, LCN2, CA125, IL-6, IL-2R, and IFN-γ levels (P<0.05). There was no significant difference in the incidence of complications between the two groups (4.87% vs 7.69%) (P>0.05). Conclusion Compare with traditional three-port thoracoscopic lobectomy, "double-microport" three-port thoracoscopic lobectomy can promote lung function recovery, reduce biochemical indicators, alleviate inflammatory response, and accelerate patient recovery.

Key words: Lung cancer, Three-port thoracoscopy, Lobectomy, Double-port, Interferon γ

摘要： 目的 对比分析“双微孔”三孔与传统三孔胸腔镜肺叶切除术对肺癌患者血清炎症因子水平的影响。方法 回顾性收集2021年1月~2024年1月期间,河南科技大学第一附属医院医治的80例肺癌患者资料,依据不同手术方法分为研究组（n=41）、对照组（n=39）,前者行双微孔三孔胸腔镜肺叶切除术,后者行传统三孔胸腔镜肺叶切除术。比较2组手术指标、手术前后肺功能[每分钟最大通气量、最大呼气流量]、生化指标[细胞角质蛋白（CYFRA21-1）、脂质运载蛋白2（LCN2）、糖类抗原125（CA125）]、炎症因子[白细胞介素-6（IL-6）、白细胞介素-2受体（IL-2R）、干扰素γ（IFN-γ）]、并发症。结果 与对照组相比,研究组胸管留放时间、住院时间、切口长度、手术时间较短,出血量和术后引流量较少（P<0.05）;与对照组相比,术后1周,研究组每分钟最大通气量、最大呼气流量较高,血清CYFRA21-1、LCN2、CA125、IL-6、IL-2R、IFN-γ水平较低（P<0.05）;2组并发症发生率相比（4.87% vs. 7.69%）相比,差异无统计学意义（P>0.05）。结论 与传统三孔胸腔镜肺叶切除术相比,“双微孔”三孔胸腔镜肺叶切除术能促进肺功能恢复,降低生化指标,减轻机体炎症反应,加快患者康复进程。

关键词: 肺癌, 三孔胸腔镜, 肺叶切除术, 双微孔, 干扰素γ