Abstract: Objective To investigate the expression levels of serum Chemokine C-X-C motif ligand 14 (CXCL14), connective tissue growth factor (CTGF) and interleukin-6 (IL-6) inpatients with different prognosis, and to analyze the correlation between the three and the severity of the disease and the predictive value of combined detection for the prognosis of patients with idiopathic pulmonary fibrosis (IPF). Methods A total of 103 patients with IPF admitted to Puyang Anyang Prefecture Hospital hospital from June 2022 to April 2023 were selected as the research objects. The patients were divided into good prognosis group (46 cases) and poor prognosis group (57 cases) according to the prognosis after 6 months of treatment. The serum levels of CXCL14, CTGF, and IL-6 between the two groups before treatment and one month after treatment were compared, as well as the pulmonary function parameters [total lung capacity (TLC), vital capacity (VC), and the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC)] and high-resolution CT (HRCT) scores one month after treatment. The correlations of serum CXCL14, CTGF, and IL-6 levels with both the pulmonary function parameters and HRCT scores were analyzed, and the predictive value of combined detection of these serum markers for the prognosis of IPF was evaluated. Results After one month of treatment, the levels of serum CXCL14, CTGF, IL-6 and the HRCT score in the poor prognosis group were higher than those in the good prognosis group, and the lung function indexes were lower than those in the good prognosis group, the differences were statistically significant (P<0.05); after one month of treatment, the levels of serumCXCL14, CTGF and IL-6 and the HRCT score were lower than those before treatment, and the lung function index was higher than that before treatment, the differences were statistically significant (P<0.05); the levels of serumCXCL14, CTGF and IL-6 was negatively correlated with lung function index and positively correlated with HRCT score, and the differences were statistically significant (P<0.05); the AUC of the levels of serum CXCL14, CTGF and IL-6 and combined prediction of poor prognosis in IPF patients were 0.788, 0.757, 0.819, 0.912, and the value of combined detection was higher than that of single index detection, the differences were statistically significant (P<0.05). Conclusion The levels of serum CXCL14, CTGF and IL-6 is closely related to the prognosis of IPF, and the combined detection of the three can provide an effective reference for predicting the poor prognosis of IPF patients.

Key words: CXCL14, CTGF, IL-6, idiopathic pulmonary fibrosis, prognosis

摘要： 目的 探讨血清趋化因子14（CXCL14）、结缔组织生长因子（CTGF）、白介素6（IL-6）水平在不同预后患者中的表达水平,分析三者与病情程度相关性及联合检测对特发性肺间质纤维化（IPF）患者预后的预测价值。方法 回顾性选取濮阳市安阳地区医院2022年6月—2023年4月收治的103例IPF患者为研究对象,依据治疗6个月后预后情况,将患者分为预后良好组（46例）、预后不良组（57例）。比较2组治疗前、治疗1个月后血清CXCL14、CTGF、IL-6水平,和2组治疗1个月后肺功能指标[肺总量（TLC）、肺活量（VC）、一秒率（FEV₁/FVC）]、高分辨率CT（HRCT）评分,分析其相关性及血清CXCL14、CTGF、IL-6水平联合检测对IPF预后的预测价值。结果 治疗1个月后,预后不良组血清CXCL14、CTGF、IL-6水平、HRCT评分高于预后良好组,肺功能指标低于预后良好组,差异有统计学意义（P<0.05）;治疗1个月后血清CXCL14、CTGF、IL-6水平、HRCT评分低于治疗前,肺功能指标高于治疗前,差异有统计学意义（P<0.05）;血清CXCL14、CTGF、IL-6水平与肺功能指标呈负相关,与HRCT评分呈正相关,差异有统计学意义（P<0.05）;血清CXCL14、CTGF、IL-6水平及联合预测IPF患者预后不良的AUC为0.788、0.757、0.819、0.912,联合检测价值高于单一指标检测,差异有统计学意义（P<0.05）。结论 血清CXCL14、CTGF、IL-6水平与IPF预后关系密切,三者联合检测可为临床预测IPF患者预后不良提供有效参考。

关键词: CXCL14, CTGF, IL-6, 特发性肺间质纤维化, 预后