Abstract: Objective To investigate the correlation between the levels of serum tripartite domain protein 27 (TRIM27), tumor necrosis factor-like weak apoptosis-inducing factor (TWEAK), and Lin-28 homolog B (Lin28B) and the pathological characteristics and clinical prognosis of endometrial cancer (EC) patients. Methods A total of 115 EC patients admitted to the Second People's Hospital of Jiaozuo from June 2021 to June 2024 were selected as the study group, and 115 healthy physical examination subjects in the same period as the control group. The levels of serum TRIM27, TWEAK and Lin28B mRNA were compared between the two groups. The levels of TRIM27, TWEAK and Lin28B mRNA in patients with different pathological characteristics and prognosis in the study group were compared. The correlation between serum TRIM27, TWEAK and Lin28B mRNA levels and pathological characteristics and prognosis was analyzed. The receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to analyze the diagnostic value of serum TRIM27, TWEAK and Lin28B mRNA for EC. Results The levels of serum TRIM27, TWEAK and Lin28B mRNA in the study group were higher than those in the control group (P<0.05). There were statistically significant differences in serum TRIM27, TWEAK and Lin28B mRNA levels in patients with different FIGO stages, tumor diameters and lymph node metastasis in the study group (P<0.05). The levels of serum TRIM27, TWEAK and Lin28B mRNA were positively correlated with FIGO stage, tumor diameter and lymph node metastasis (P<0.05). The AUC of serum TRIM27, TWEAK and Lin28B mRNA alone and combined diagnosis of EC was 0.712, 0.735, 0.685 and 0.857, respectively, and the combined AUC was the highest. The levels of serum TRIM27, TWEAK and Lin28B mRNA in patients with good prognosis were lower than those in the control group (P<0.05). Serum TRIM27, TWEAK and Lin28B mRNA levels were positively correlated with prognosis (P<0.05). Conclusion The high expression of TRIM27, TWEAK, and Lin28B mRNA in the serum of EC patients is closely related to their pathological characteristics and prognosis. TRIM27, TWEAK, and Lin28B can serve as auxiliary markers for diagnosing EC.

Key words: TRIM27, TWEAK, Lin28B, endometrial cancer, pathological characteristics, prognosis

摘要： 目的 探讨血清三结构域蛋白27（TRIM27）、肿瘤坏死因子样弱凋亡诱导因子（TWEAK）、Lin-28同系物B（Lin28B）水平与子宫内膜癌（EC）患者病理特征及临床预后的相关性。方法 选取2021年6月—2024年6月焦作市第二人民医院收治的115例EC患者作为研究组,并选取同期115名健康体检者作为对照组。比较2组血清TRIM27、TWEAK、Lin28B mRNA水平,研究组不同病理特征、预后患者TRIM27、TWEAK、Lin28B mRNA水平,分析血清TRIM27、TWEAK、Lin28B mRNA水平与病理特征、预后的相关性,通过受试者工作特征（ROC）曲线及曲线下面积（AUC）分析血清TRIM27、TWEAK、Lin28B mRNA对EC的诊断价值。结果 研究组血清TRIM27、TWEAK、Lin28B mRNA水平高于对照组（P<0.05）;研究组不同FIGO分期、肿瘤直径、淋巴结转移患者血清TRIM27、TWEAK、Lin28B mRNA水平相比,差异有统计学意义（P<0.05）;血清TRIM27、TWEAK、Lin28B mRNA水平与FIGO分期、肿瘤直径、淋巴结转移呈正相关（P<0.05）;血清TRIM27、TWEAK、Lin28B mRNA单独及联合诊断EC的AUC分别为0.712、0.735、0.685、0.857,联合诊断AUC最高;预后良好患者血清TRIM27、TWEAK、Lin28B mRNA水平低于对照组（P<0.05）;血清TRIM27、TWEAK、Lin28B mRNA水平与预后呈正相关（P<0.05）。结论 EC患者血清TRIM27、TWEAK、Lin28B mRNA处于高表达状态,与患者病理特征、预后密切相关,TRIM27、TWEAK、Lin28B可用于辅助诊断EC。

关键词: TRIM27, TWEAK, Lin28B, 子宫内膜癌, 病理特征, 预后