Abstract: Objective: To explore the effects and prognosis of radiofrequency ablation (RFA) under color Doppler ultrasound guidance in the treatment of benign thyroid nodules. Methods: 146 benign thyroid nodules patients were all treated with RFA under color Doppler ultrasound guidance. The symptoms scores, signs scores, thyroid function, changes of thyroid nodules and prognosis of patients were observed before and after surgery. Results: 1 year after surgery, the symptoms scores and signs scores of patients were all lower than that before surgery remarkably (P<0.05). The free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) of patients 1 year after surgery had no statistically significant difference compared with that before surgery (P>0.05). Compared with that before surgery, the mean maximum diameter of nodules and nodules volume at 1 month, 1 year, 2 years and 3years after surgery reduced remarkably (P<0.05). Compared with that 1 month after surgery, the volume reduction rate (VRR) at 1 year, 2 years and 3years after surgery increased remarkably (P<0.05). Follow-up for 3 years, the cure rate of 146 patients was 9.5% (14/146), the effective rate was 100% (146/146), and no case recurred. Conclusions: RFA under color Doppler ultrasound has significant long-term effects and good prognosis in the treatment of benign thyroid nodules, thus it is worthy of clinical promotion.

Key words: Color Doppler ultrasound, Radiofrequency ablation (RFA), Benign thyroid nodules, Prognosis

摘要： 目的:探讨彩超引导下射频消融术（RFA）治疗甲状腺良性结节的效果及预后。方法:146例甲状腺良性结节患者均在彩超引导下行RFA治疗,观察患者术前、术后症状评分和体征评分、甲状腺功能、甲状腺结节的变化情况及预后。结果:术后1年,患者症状评分和体征评分均明显低于术前,差异有统计学意义（P<0.05）;术后1年,患者游离三碘甲状腺原氨酸（FT3）、游离甲状腺激素（FT4）、促甲状腺激素（TSH）水平与术前比较,差异无统计学意义（P>0.05）;与术前比较,术后1个月、术后1年、术后2年和术后3年,结节最大径、结节体积均显著缩小（P<0.05）;与术后1个月比较,术后1年、术后2年和术后3年VRR均显著增大（P<0.05）。随访3年,146例患者治愈率为9.5%（14/146）、显效率为100%（146/146）,无1例复发。结论:彩超引导下RFA治疗甲状腺良性结节远期效果显著,值得临床推广。

关键词: 彩色多普勒超声, 射频消融术, 甲状腺良性结节, 预后