Abstract: Objective: To study the changes and significance of CD4 and CD8 expression in skin lesions of patients with erythema nodosum. Methods: MaxVision^TM immunohistochemical stain was used to detect the expression of CD4 and CD8 in skin lesions of 49 cases of erythema nodosum patients (disease group) and 10 cases of normal skin (control group). Results: The CD4 positive rate of disease group was 100.00%, which was obviously higher than control group (P<0.01). There was no significant difference of positive rate of CD8 expression between disease group and control group (P>0.05). Conclusions: There is an imbalance of T cells subgroups in skin lesions of erythema nodosum patients, which suggests that the cellular immune response mediated by CD4⁺ T cells plays an important role in the pathogenesis of erythema nodosum.

Key words: Erythema nodosum, Immunohistochemistry, CD4, CD8

摘要： 目的: 分析结节性红斑患者皮损处CD4、CD8表达的变化及意义。方法: 采用MaxVision^TM免疫组织化学染色法检测49例结节性红斑患者皮损组织（疾病组）及10例正常皮肤组织（对照组）CD4、CD8的表达情况。结果: 疾病组CD4阳性率为100.00%,明显高于对照组（P<0.01）。疾病组、对照组CD8分子阳性率分别比较差异无统计学意义（P>0.05）。结论: 结节性红斑患者皮损处存在T细胞亚群的失衡,考虑CD4⁺T细胞介导的细胞免疫在结节性红斑的发病中具有重要作用。

关键词: 结节性红斑, 免疫组织化学, CD4, CD8