Abstract: Objective: To characterize the clinical distribution and drug resistance of hospital-acquired infections due to Enterococcus spp and provide basis for clinical treatment. Methods: The clinical data of hospital-acquired enterococcus infection patients from 2013.1 to 2015.12 in Chinese PLA General Hospital were retrospectively analyzed. Results: A total of 883 strains of Enterococci were isolated in this study. Most of them were isolated from ICU (292 strains, 33.07%) and hepatobiliary surgery department (125 strains, 14.16%); Urine was the most common sources of these strains (347, 39.30%), followed by body fluids (315, 35.67%) and blood samples (202, 22.88%); The top organism was Enterococcus faecium (596, 67.50%), followed by Enterococcus faecalis (244, 27.63%). The resistance rates of Enterococcus faecium to ampicillin, penicillin, streptomycin, tetracycline, erythromycin, vancomycin and ciprofloxacin were obviously higher than Enterococcus faecalis (P<0.05). Conclusions: Enterococcus faecium and Enterococcus faecalis are the main pathogens in hospital-acquired enterococcus infection, and Enterococcus faecalis has higher resistance rate. It's necessary to choose the appropriate antibiotics according to drug susceptibility test in clinical treatment.

Key words: Enterococcus spp., Clinical distribution, Drug resistance

摘要： 目的: 了解医院获得性肠球菌属细菌感染的分布及耐药特点,为临床治疗提供依据。方法: 回顾性分析中国人民解放军总医院2013年1月至2015年12月医院获得性肠球菌属细菌感染患者的临床资料。结果: 共分离肠球菌属细菌883株。细菌来源科室主要为ICU（292株,33.07%）和肝胆外科（125株,14.16%）;标本分布以尿液最多见（347株,39.30%）,其次为体液（315株,35.67%）和血标本（202株,22.88%）;分离的肠球菌属细菌中屎肠球菌数目最多（596株,67.50%）,其次为粪肠球菌（244株,27.63%）。屎肠球菌对氨苄西林、青霉素、链霉素、四环素、红霉素、万古霉素和环丙沙星的耐药率均高于粪肠球菌（P<0.05）。结论: 医院获得性肠球菌属细菌感染以屎肠球菌和粪肠球菌为主,屎肠球菌具有更高的耐药率,临床治疗需依据药敏结果合理选用抗菌药物。【关键词】 肠球菌属;临床分布;耐药性

关键词: 肠球菌属, 临床分布, 耐药性