Abstract: Objective To study the features of clinical, dermoscopic and pathological of Seborrheic Keratosis and analyze their correlation. Methods Sixty-one patients with Seborrheic Keratosis diagnosed by histomathological examination and dermoscopy, who were admitted to the Affiliated Hospital of Chengde Medical University from March 2017 to December 2019, were selected to analyze the relationship between different clinical features, dermoscopy findings and pathological features of skin lesions. Results Under the dermoscope of fissures/ brain pattern appearance, comedo-like openings,milia-like cysts, the proportion of clinical papule, plaque and nodule was higher than that of macule, patch and verruca/papilla, and the differences were statistically significant (P<0.05). There were positive correlation between fissures/brain pattern appearance and hyperkeratosis and acanthosis (P<0.05). There were positive correlations between comedo-like openings, punctiform/hairpin blood vessels, milia-like cysts and acanthosis (P<0.05). Conclusion The diagnostic rate of seborrheic keratosis could be improved by the combination of dermoscopic examination and clinical features, and the accurate rate of diagnose of dermoscopy and pathology is highly consistent.

Key words: seborrheic keratosis, dermatoscopy, histopathology

摘要： 目的 研究脂溢性角化病的临床特征、皮肤镜表现、病理特点及其相关性分析。方法 选取2017年3月~2019年12月就诊于承德医学院附属医院,经组织病理检查和皮肤镜检查,诊断为脂溢性角化病的患者61例,分析其皮损的不同临床特征、皮肤镜表现与病理特点的关系。结果 皮肤镜下裂隙/脑回样外观、粉刺样开口、粟粒样囊肿模式中,临床特征为丘疹、斑块、结节的占比高于斑疹、斑片及疣状/乳头状,差异均有统计学意义（P<0.001）;皮肤镜下裂隙/脑回样外观与病理角化过度型、棘层肥厚型均呈正相关（P<0.05）,粉刺样开口、点状/发卡样血管结构、粟粒样囊肿均与病理棘层肥厚呈正相关（P<0.05）。结论 皮肤镜检查结合临床特征有助于提高脂溢性角化病临床诊断准确性,且皮肤镜诊断与病理诊断有较高的一致性。

关键词: 脂溢性角化病, 皮肤镜, 组织病理