Abstract: Objective To explore the correlation between lipoprotein-associated phospholipase A2 (Lp-PLA2) and annexin A2 (Annexin A2) with prognosis in patients with acute ischemic stroke (AIS) after thrombolysis. Methods A total of 65 AIS patients undergoing thrombolysis in the hospital were enrolled as the research objects between June 2017 and October 2019. According to curative effect of thrombolysis, patients were divided into favourable prognosis group and unfavourable prognosis group. The clinical data and protein levels of Lp-PLA2, Annexin A2 and recombinant parkinson disease protein 7 (PARK7) were compared between the two groups. According to NIHSS scores, patients were divided into mild, moderate and severe groups, and comparison was conducted among the three groups. The correlation among Lp-PLA2, Annexin A2 and PARK7 was analyzed by Pearson correlation analysis. The predictive efficiency of Lp-PLA2, Annexin A2, PARK7 and their combination for prognosis of AIS patients after thrombolysis was analyzed by receiver operating characteristic (ROC) curves. Results The levels of Lp-PLA2, Annexin A2 and PARK7 in unfavourable prognosis group were significantly higher than those in favourable prognosis group (P<0.05). With the exacerbation of disease, the levels of Lp-PLA2, Annexin A2 and PARK7 in AIS patients were gradually increased (P<0.05). The results of Pearson analysis showed that the above three indexes in AIS patients were positively correlated (P<0.05). The results of ROC curve analysis showed that AUC values of Lp-PLA2, Annexin A2 and PARK7 for predicting prognosis of AIS patients were 0.837, 0.830 and 0.696, lower than 0.878 of their combination. Conclusion Lp-PLA2, Annexin A2 and PARK7 are closely related to the severity and prognosis of AIS patients. The combination of the three is of relatively higher predictive value for the prognosis of AIS patients after thrombolysis.

Key words: acute ischemic stroke, lipoprotein-associated phospholipase A2, annexin A2, prognosis

摘要： 目的 探究脂蛋白相关磷脂酶A2（Lp-PLA2）、膜联蛋白A2（Annexin A2）与溶栓后急性缺血性脑卒中（AIS）患者预后的相关性。方法 选取2017年6月~2019年10月入院接受溶栓治疗的AIS患者65例作为研究对象。根据溶栓治疗效果分为预后良好组及预后不良组。比较两组临床资料,对两组Lp-PLA2、Annexin A2、帕金森蛋白7（PARK7）蛋白水平进行比较;根据NIHSS评分将患者分为轻中重度三组,并进行比较;利用Pearson相关性分析对溶栓后AIS患者三者水平的相关性进行分析,利用受试者工作特征曲线（ROC）分析三者单独及联合对溶栓后AIS患者预后的预测效果。结果 预后不良组Lp-PLA2、Annexin A2、PARK7水平明显高于预后良好组（P<0.05）;随着病情严重程度增加,AIS患者Lp-PLA2、Annexin A2、PARK7水平逐渐升高（P<0.05）;Pearson分析结果表明,AIS患者上述三者水平呈正相关（P<0.05）;ROC曲线分析结果表明,Lp-PLA2、Annexin A2、PARK7三者对AIS患者预后预测的AUC分别为0.837、0.830、0.696,低于三者联合预测的0.878。结论 Lp-PLA2、Annexin A2、PARK7与AIS患者病情严重程度及预后密切相关,三者联合对溶栓后AIS患者预后具有良好的预测价值。

关键词: 急性脑卒中, 脂蛋白相关磷脂酶A2, 膜联蛋白A2, 预后