Abstract: Objective: To investigate the efficacy and safety of treating idiopathic trigeminal neuralgia with pulsed radiofrequency combined adriamycin.Methods: 90 idiopathic trigeminal neuralgia patients failed to conservative treatment were randomly divided into adriamycin (ADM) group, pulsed radiofrequency combined adriamycin (PRF+ADM) group and PRF group with 30 patients in each group.The VAS score,PRI score,effective rate and complications of patients in 3 groups were compared. Results: The VAS score, PRI score of patients in PRF+ADM were obviously lower than that of patients in PRF group at each time point after treatment,but the effective rate was obviously higher (P<0.05). The VAS score, PRI score and effective rate had statistical difference between PRF+ADM group and ADM group 1d and 3d after treatment (P<0.05); There had no statistical significance of VAS score, PRI score and effective rate between PRF+ADM group and ADM group at other time point after treatment. There were no obvious complications in 3 groups. Conclusions: Treating idiopathic trigeminal neuralgia with pulsed radiofrequency combined adriamycin can get better short-term and long term effects, as well as higher security, so it is worthy of clinical application.

Key words: Idiopathic trigeminal neuralgia, Pulsed radiofrequency, Adriamycin, Trigeminal ganglion, Treatment

摘要： 目的: 探讨脉冲射频联合阿霉素治疗原发性三叉神经痛的疗效和安全性。方法: 90例原发性三叉神经痛经保守治疗无效的患者随机分为三组（n=30）,单纯阿霉素组（ADM组）、脉冲射频联合阿霉素组（PRF+ADM组）和单纯脉冲射频组（PRF组）,比较三组患者的VAS评分、PRI总分、治疗有效率和并发症情况。结果:治疗后各时间点PRF+ADM组VAS评分、PRI总分明显低于PRF组,治疗有效率明显高于PRF组（P<0.05）。术后1d、3d PRF+ADM组各指标与ADM组比较,差异有统计学意义（P<0.05）;其它各时间点两组各观察指标比较,差异无统计学意义。三组患者均未出现明显并发症。结论: PRF联合ADM治疗三叉神经痛近、远期疗效均较好,且安全性高,值得临床推广应用。

关键词: 原发性三叉神经痛, 脉冲射频, 阿霉素, 三叉神经节, 治疗