Abstract: Objective: To evaluate the intervention effects of parenteral nutrition with different nitrogen-content onnutriture and immune indice of patients with gastrointestinal tumors after surgery. Methods: 50 patients with gastrointestinal tumors after surgery were randomly divided into experimental group and control group with 25 patients in each group. All the patients were given total parenteral nutrition through central vein on the first day after operation, and the non-protein calorie were all 83.7-104.6kJ/(kg•d). Meanwhile, the nitrogen-content of experimental group was 0.20g(0.15-0.22g)/(kg•d), while the control group was 0.10g(0.09-0.11 g)/(kg•d). The hemoglobin, albumin, CD₃⁺, CD₄⁺ and CD₄⁺/CD₈⁺ of patients in 2 groups on the 14^th day after operation were compared. Results: 14^th day after operation, the hemoglobin, albumin, CD₃⁺, CD₄⁺ and CD₄⁺/CD₈⁺ of patients in experimental group were all obviously higher than control group (P<0.05). Conclusions: On the basis of giving the same heat quantity, total parenteral nutrition provided by normal nitrogen-content [0.20g/(kg•d)] can improve the nutritional and immune status of patients after gastrointestinal tumor surgery.

Key words: Gastrointestinal tumor, Total parenteral nutrition, Nitrogen-content, Intervention effects

摘要： 目的: 评价不同氮量全肠外营养支持对胃肠肿瘤患者术后营养状况和免疫指标的影响。方法: 50例胃肠肿瘤术后患者随机分为实验组和对照组,每组25例。两组患者均于术后第1d开始经中心静脉行全肠外营养,非蛋白热量均为83.7-104.6kJ/(kg·d);同时,实验组氮量按0.20g(0.15-0.22g)/(kg·d)给予,对照组氮量按0.10g(0.09-0.11g)/(kg·d)。比较两组患者术后第14d的血红蛋白、白蛋白,CD₃⁺、CD₄⁺和CD₄⁺/CD₈⁺值。结果: 术后第14d,实验组患者血红蛋白、白蛋白,CD₃⁺、CD₄⁺和CD₄⁺/CD₈⁺值均明显高于对照组（P<0.05）。结论: 在给予相同热量的基础上,按正常氮量[0.20g/(kg·d)]供给的全肠外营养有助于改善胃肠肿瘤术后患者的营养和免疫状况。

关键词: 胃肠肿瘤, 全肠外营养, 氮量, 干预作用