Objective: To analyze the effects and prognosis of laparoscope in the treatment of gallbladder stone withcholecystitis. Methods: 116 cases of gallbladder stone with cholecystitis patients were divided into observation group and control group with 58 patients in each group according to operation method. The patients in observation group were treated with laparoscopic surgery, while the patients in control group were treated with traditional open surgery. The indexes during and after operation, as well as postoperative quality of life of patients in 2 groups were compared. Results: The operation time, intraoperative blood loss, utilization rate of anodynes, time of leaving bed, bowel sounds recovery time and hospital stays of patients in observation group were obviously lower than control group (P<0.05). The field of social relation, psychology, physiology, environment, the gemeingefuhl and total score of patients in observation group were obviously higher than control group (P<0.05). Conclusions: Treating gallbladder stone with cholecystitis with laparoscope has significant effects, it can effectively improve the quality of life and prognosis of patients.