Objective: To investigate the clinical effects of iRoot BP on repairing perforation of pulp floor. Methods: Forty patients with perforation of pulp floor were selected in this study and randomly divided into observation group (n=20) and control group(n=20). The patients in observation group were repaired with iRoot BP, while the patients in control group were repaired with mineral trioxide (MTA). The success ratio of the reparation of patients in 2 groups 3 months, 6 months, 12 months after treatment were compared, as well as the incidence of complications and satisfaction rate of repair treatment of 2 groups were recorded and compared. Results: The success ratio of the reparation of patients in observation group 3 months and 6months were significantly higher than control group (P<0.05); There was no significant difference about success ratio of the reparation 12 months after treatment of 2 groups (P>0.05). None of the patients in observation group suffered occlusal pain and loose teeth, and the complication rate of observation group was 0.00%, which was significantly lower than control group (20.00%, P<0.05). The satisfaction rate of repair treatment of observation group was 95.00%, which was significantly higher than control group (65.00%, P<0.05). Conclusions: The treatment effects of iRoot BP for treating perforation of pulp floor are better than MTA, the safety and satisfaction rate of repair treatment are all higher, so it is worthy of clinical application.