Objective To explore the predictive value of serum levels of nuclear receptor subfamily C member 2 (NR3C2), progesterone receptor membrane component 1 (PGRMC1), and carbohydrate antigen 153 (CA153) in predicting postoperative recurrence and metastasis in breast cancer patients. Methods A retrospective study was conducted on 102 breast cancer patients who underwent modified radical mastectomy at Nanyang Central Hospitall from January 2021 to January 2023. Patients were divided into two groups based on whether they experienced recurrence or metastasis one year after surgery: the occurrence group (38 cases) and the non-occurrence group (64 cases). Serum levels of NR3C2 and PGRMC1 were detected using ELISA, and serum CA153 levels were detected using immunochemical luminescence. The predictive value of serum NR3C2, PGRMC1, and CA153 for postoperative recurrent metastasis was analyzed using ROC. Results The postoperative serum levels of NR3C2 in the occurrence group were lower than those in the non-occurrence group, while the levels of PGRMC1 and CA153 were higher (P<0.05). Partial correlation analysis revealed that NR3C2 was negatively correlated with postoperative recurrence and metastasis, whereas PGRMC1 and CA153 were positively correlated (P<0.05). The AUC values for predicting postoperative 1-year recurrence and metastasis using serum levels of NR3C2, PGRMC1, and CA153, either individually or in combination, were 0.771, 0.775, 0.825, and 0.909, respectively, 2 months post-surgery. Notably, the AUC value for combined prediction was higher than that for individual indicators (P<0.05). Conclusion Serum NR3C2, PGRMC1, and CA153 have certain predictive value for postoperative recurrence and metastasis in breast cancer patients, and combined detection can improve the predictive efficacy.

Objective: To investigate the diagnostic value of plasma D-dimmer level combined with Wells score for chronic heart failure (CHF) suspected with lower limb deep venous thrombosis (LDVT). Methods: The clinical data of 100 CHF patients suspected with LDVT were retrospectively analyzed. The patients were diagnosed respectively by plasma D-dimmer level, Wells score and combination of the two methods; The results were compared with the diagnostic results of color Doppler at the same time. Results: The sensitivity, specificity and accuracy of D-dimmer for diagnosing LDVT was 84.71%, 40.00% and 78.00% respectively. The consistency between D-dimmer and color Doppler was poor (Kappa=0.223). The sensitivity, specificity and accuracy of Wells score for diagnosing LDVT was 94.12%, 60.00% and 89.00% respectively. The consistency between Wells score and color Doppler was general (Kappa=0.556). The sensitivity, specificity and accuracy of D-dimmer combined with Wells score for diagnosing LDVT was 98.82%, 73.33% and 95.00% respectively. The consistency between combination of above two methods and color Doppler was better (Kappa=0.786). Conclusions: D-dimmer combined with Wells score has higher sensitivity and accuracy for diagnosing CHF suspected with LDVT, which is simple and rapid, and has the value of clinical promotion.