Objective: To analyze the relationships between apolipoprotein B/A1, glycosylated hemoglobin (HbA1c) level and venous thrombolytic outcome in acute cerebral infarction patients. Methods: 76 acute cerebral infarction patients were all treated with recombinant tissue plasminogen activator (rt-PA) venous thrombolysis, and the patients were divided into ineffective group (n=27) and effective group (n=49) according to improvement of NIHSS score before and after thrombolysis. The blood glucose, blood lipid, HbA1c and other indicators of all the patients were detected. Results: The HbA1c, ApoB and ApoB/A1 of patients in effective group were significantly lower than ineffective group, the ApoA1 was significantly higher (P<0.05). Logistic regression analysis showed that age, HbA1c and ApoB/A1 were independent risk factors for thrombolytic outcome (P<0.05). Conclusions: ApoB/A1 and HbA1c may has certain predicting value for thrombolytic outcome in acute cerebral infarction patients at early stage.

Objective: To investigate the changes and significance of plasma fibrinogen (FIB) and D-dimer level in patients with different types small vessel disease (CSVD). Methods: The plasma FIB and D-dimer level of 134 CSVD patients and 75 controls were detected and the risk factors of CSVD were analyzed. Results: The ratio of hypertension, plasma FIB level and plasma D-dimer level of CSVD and its subtypes (lacunar infarction/LI, white matter lesions/WML, LI combined WML) patients were all obviously higher than controls (P<0.05). Logistic regression analysis showed that D-dimer was risk factor for CSVD, LI, WML and LI combined WML (P<0.05); FIB was risk factor for CSVD, LI and LI combined WML (P<0.05). Conclusions: As risk factors for CSVD, FIB and D-dimer involve in the development of CSVD, but the risk factors for subtypes of CSVD are different.

Objective: To observe the relationships between serum matrix metalloproteinase-9 (MMP-9) level and cognitive dysfunction after cerebral infarction of patients with acute cerebral infarction. Methods: Initial cerebral infarction patients were divided into cognitive dysfunction group (≤26) and non cognitive dysfunction group (<26) according to MoCA score. Healthy checkup at the same term were taken as healthy control group. ELISA was used to detect the serum MMP-9 level of 124 subjects. Results: The serum MMP-9 level of patients in cognitive dysfunction group was obviously higher than non cognitive dysfunction group and healthy control group (P<0.05). Logistic regression showed that MMP-9 and age were independent risk factors for cognitive dysfunction after cerebral infarction. Conclusions: Increasing of serum MMP-9 level in patients with acute cerebral infarction maybe related to cognitive dysfunction after cerebral infarction.