Objective: To study the expression and significance of migration induced protein-7 (MIG-7) and matrix metalloproteinase-2 (MMP-2) in colon cancer. Methods: Immunohistochemical staining was used to detect the expression of MIG-7 and MMP-2 in 70 cases of colon cancer tissues and corresponding adjacent normal tissues. The relationships between MIG-7, MMP-2 and the clinicopathological characteristics of colon cancer, and the correlations between MIG-7 and MMP-2 in colon cancer tissues were also analyzed. Results: The positive expression rate of MIG-7 and MMP-2 in 70 cases of colon cancer tissues were 61.43% and 70.00% respectively, which were all singnificantly higher than adjacent normal tissues (P˂0.05). In colon cancer, the expression of MIG-7 and MMP-2 were related to differentiation and lymph node metastasis (P˂0.05); but irrelevant to sex, age and tumor size (P>0.05). In colon cancer, the expression of MIG-7 was positively correlated with MMP-2 (r=0.506,P˂0.05). Conduidons: MIG-7 and MMP-2 may participate in the growth and metastasis of colon cancer together.

Objective: To investigate the expression and clinical significance of Zinc finger E box homologous protein-1 (ZEB1) and lysyloxidase-2 (LOXL2) in colon cancer. Methods: MaxVision immunohistochemical method was used to detect the expressions of ZEB1 and LOXL2 protein in 72 cases of colon cancer tissues and 36 cases of para-carcinoma tissues. The correlations of ZEB1 and LOXL2 in colon cancer, as well as the relationships between ZEB1, LOXL2 expression and clinicopathologic features of colon cancer were also analyzed. Results: The positive expression rate of ZEB1 and LOXL2 in colon cancer were obviously higher than para-carcinoma tissues (P<0.05). In colon cancer, the expression rate of ZEB1 and LOXL2 was related to infiltration depth, TNM stage and lymph node metastasis (P<0.05); but irrelevant to age, sex and differentiated degree (P>0.05). In colon cancer, the ZEB1 expression was positively correlated to LOXL2 expression (r=0.30, P<0.05). Conclusions: ZEB1 and LOXL2 are highly expressed and positively correlated in colon cancer, which suggest that ZEB1 and LOXL2 maybe involve in the development, invasion and metastasis of colon cancer together.

Objective: To investigate the expression and clinical significance of serum/glucocorticoid regulated kinase 3 (SGK3) in colon cancer. Methods: SP immunohistochemical method was used to detect the expression of SGK3 in 70 cases of colon cancer tissues and 30 cases of adjacent normal tissues; And the relationships between SGK3 expression and pathological features of colon cancer were also analyzed. Results: The SGK3 expression in colon cancer was 74.3% (52/70), which was significantly higher than that in adjacent normal tissue (16.7%, 5/30) (P<0.05). In colon cancer, the SGK3 expression was related to TNM stage, depth of invasion and lymph node metastasis (P<0.05); but was irrelevant to age, gender, tumor size and histopathological differentiation (P>0.05). Conclusions: High expression of SGK3 may participate the development of colon cancer, and maybe related with the poor prognosis of colon cancer.

Objective: To investigate the expression and clinical significance of Six1 and E-cad in colon cancer. Methods: SP immunohistochemical method was used to detect Six1 and E-cad expression in 70 cases of colon cancer and 30 cases of adjacent normal tissue; and the correlations between Six1, E-cad and the clinical pathological characteristics of colon cancer were also analyzed. Results: The positive expression rate of Six1 in colon cancer was obviously higher than adjacent normal tissue, but the positive expression rate of E-cad was obviously lower (P<0.01). The Six1 and E-cad expression in colon cancer was not related to sex, age, size of tumour and differentiation degree (P＞0.05); But related to TNM stage and infiltration depth (P＜0.05). The expression of Six1 in colon cancer was negative correlated to E-cad expression (r=-0.480, P＜0.01). Conclusions: E-cad and Six1 maybe involved in development of colon cancer together; Moreover, E-cad and Six1 expression is closely related to poor prognosis of colon cancer.