Objective: To investigate the clinical effects of restrictive fluid resuscitation and conventional fluid resuscitation on patients with shock and trauma induced coagulopathy (TIC). Methods: 78 patients with shock and TIC were randomly divided into routine treatment group (n=39) and restriction group (n=39). Conventional fluid resuscitation was used in routine treatment group, while restrictive fluid resuscitation was used in restriction group. The blood gas analysis indexes, coagulation function, incidence of complications and survival rate of patients in 2 groups were compared. Results: 60 min and 120 min after resuscitation, the pH and PaO ₂ of patients in restriction group were obviously higher than routine treatment group, but the PaCO ₂, PT, APTT, TT were obviously lower (P<0.05). 24h after resuscitation, the incidence of acute respiratory distress syndrome, disseminated intravascular coagulation and multiple organ failure of patients in restriction group were obviously lower than routine treatment group (P<0.05); the survival rated of restriction group 1 week after resuscitation was obviously higher than routine treatment group (P<0.05). Conclusions: Treating shock and TIC patients with restrictive fluid resuscitation can improve the blood gas analysis indexes and coagulation function better, and reduce complications effectively, so it is worthy of popularizing application in clinic.