ISSN 1004-6879
CN 13-1154/R
Journal of Chengde Medical University
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EXPRESSION AND CLINICAL SIGNIFICANCE OF IGFBP-3 AND MMP-14 IN COLORECTAL CANCER
SUN Li-yuan, LIU Xiao-qian, XUE Jing, et al
Abstract
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73
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Objective:
To investigate the expression and clinical significance of insulin-like growth factor binding protein-3 (IGFBP-3) and matrix metalloproteinases-14 (MMP-14) in colorectal cancer (CRC).
Methods:
Immunohistochemical staining was used to detect the expression of IGFBP-3 and MMP-14 in 70 cases of CRC, 30 cases of colorectal adenoma (CRA) and 20 cases of normal colorectal mucosa (NM). The relationships between IGFBP-3, MMP-14 and clinical pathological features of CRC, as well as the correlations between IGFBP-3 and MMP-14 in CRC were analyzed.
Results:
In CRC, the MMP-14 protein expression was obviously higher than CRA and NM; the MMP-14 expression was concerned with depth of invasion, lymph node metastasis and Dukes stage (P<0.01, P<0.05). In CRC, the IGFBP-3 protein expression was obviously lower than CRA and NM; the IGFBP-3 expression was concerned with lymph node metastasis and Dukes stage (P<0.05). In CRC, the expression of MMP-14 was negatively correlated with the expression of IGFBP-3 (r=-0.460, P<0.05).
Conclusions:
IGFBP-3 and MMP-14 may have synergistic effects and participate in the process of development, invasion and metastasis of CRC jointly.
2018, 35 (2): 91-93.
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EXPRESSION AND SIGNIFICANCE OF IGF-I, IGF-IR AND GLUT-4 IN COLORECTAL CARCINOMA
LIU Xiao-qian, SUN Li-yuan, LIU Sha-sha, et al
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92
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Objective:
To investigate the expression and significance of insulin-like growth factor-I (IGF-I), insulin-like growth factor-I receptor (IGF-IR) and glucose transporter-4 (GLUT-4) in colorectal carcinoma.
Methods:
Immunohistochemical stain was used to detect the expression of IGF-I, IGF-IR and GLUT-4 protein in 70 cases colorectal carcinoma, 30 cases colorectal adenoma and 20 cases normal colorectal mucosa; and the correlations of aboving three factors in colorectal carcinoma were also analyzed.
Results:
The expression of IGF-I, IGF-IR and GLUT-4 in colorectal carcinoma were significantly higher than that of normal colorectal mucosa and colorectal adenoma(P<0.01). In colorectal carcinoma, the expression of IGF-I was positively correlated with IGF-IR and GLUT4 (r=0.412,0.396, P<0.01).
Conclusions:
IGF-I, IGF-IR and GLUT-4 may play an important role in development of colorectal carcinoma.
2018, 35 (1): 8-11.