Objective: To study the expression and clinical significance of tumor necrosis factor-α (TNF-α) and interleukin -12 (IL-12) in invasive pituitary tumors (invasive pituitary adenomas, IPA). Methods: Immunohistochemical staining (Max Vision two-step method) was used to detect the expression of TNF-α and IL-12 in 40 cases of IPA and 40 cases of non-IPA tissues. Results: The positive expression rate of TNF-α in IPA (65.0%) was remarkably higher than non-IPA tissues, while the positive expression rate of IL-12 (32.5%) was remarkably lower (P<0.05). Conclusions: TNF-α and IL-12 may play important role in development of IPA.

Objective:To investigate the changes and clinical significance of serum tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) level in patients with hypertensive cerebral hemorrhage (HICH). Methods:ELISA was used to detect the serum TNF-α, VEGF and ET-1 level of HICH patients and healthy controls; And the serum TNF-α, VEGF and ET-1 level of HICH patients with different GCS scores were analyzed. Results:The serum TNF-α, VEGF and ET-1 level of HICH patients were significantly higher than healthy controls (P<0.05). Along with decreasing of GCS score in HICH patients, the serum TNF-α, VEGF and ET-1 level gradually increased (P<0.05). Conclusions:Detection of serum TNF-α, VEGF and ET-1 level play important role in diagnosis and prognosis of HICH patients.