Objective To observe the changes of Betatrophin levels in type 2 diabetes mellitus combined with metabolism-related fatty liver diseases, and explore its predictive value for the disease. Methods A total of 58 patients with T2DM were admitted to the Department of Endocrinology and Metabolism in The Second Affiliated Hospital of Bengbu Medical College from January 2021 to November 2021 were selected as the case group. According to whether they had combined metabolic related fatty liver disease, patients were divided into T2DM with MAFLD group and T2DM alone group. Healthy subjects were selected as control group. We compared the general data, serum Betatrophin, blood glucose and lipid profiles, and analyzed the association between Betatrophin and type 2 diabetes mellitus with metabolic related fatty liver disease. Results There were significant differences in BMI, ALT, FPG, HOMA-IR, HbA1c, TG, LDL-C, HDL-C, Betatrophin between case group and control group (P<0.05). There were significant differences in BMI, HOMA-IR, HbA1c, TG and Betatrophin between T2DM with MAFLD group and T2DM alone group (P<0.05). Correlation analysis found that Betatrophin was positively correlated with TG. Multivariate analysis identified Betatrophin with TG as an independent risk factor for combined metabolic related fatty liver disease in patients with type 2 diabetes (P<0.05). Conclusion Betatrophin levels are significantly increased in the serum of T2DM patients with MAFLD, which promotes disease initiation and progression, and has predictive value for MAFLD.

Objective: To investigate the clinical effects of bedside ultrasound-guided central venous catheterization in patients with hypovolemic shock. Methods: 136 patients with hypovolemic shock that underwent central venous catheterization in ICU were divided into experimental group (bedside ultrasound-guided central venous catheterization) and control group (Seldinger puncture catheterization) according to catheterization mode. The catheterization time, success rate of puncture and incidence of complications of patients in 2 groups were compared. Results: The catheterization time of patients in experimental group was (7.2±1.8)min, which was obviously shorter than control group (10.6±2.1min, P<0.05). The first, second and third success rate of puncture of patients in experimental group were respectivley 94.3%, 98.6% and 100.0%, which were all obviously higher than control group (P<0.05). The incidence rate of local hematoma formation and mispuncture of artery of patients in experimental group were obviously lower than control group (P<0.05). Conclusions: Bedside ultrasound-guided central venous catheterization can increase the success rate of catheterization of patients with hypovolemic shock, also can shortern catheterization time and reduce complications, so has better application value.

Objective: To study the clinical effects of salvianolate on treating non-ST segment evaluation acute coronary syndrome(NSTE-ACS). Methods: 89 NSTE-ACS patients were randomly divided into observation group (n=45) and control group (n=44). All the patients were treated according to the NSTE-ACS treatment guidelines; on this basis, the patients in observation group were also given salvianolate; And the course of the treatment was 7 days. The efficiency of treatment for 7 days, the serum cTnI, C-reactive protein (CRP) and malonaldehyde (MDA) level before treatment, 3 days after treatment, 7 days after treament of patients in 2 groups were compared. Results: There was no significant difference in the effective rate between observation group and control group (P>0.05). The serum cTnI, CRP and MDA level 3 days and 7days after treatment of patients in observation group were obviously lower than control group (P<0.05). Conclusions: Salvianolate can improve the inflammation and oxidative stress level of NSTE-ACS patients, so has protective effects on myocardium.