Objective: To investigate the expression and clinical significance of serum/glucocorticoid regulated kinase 3 (SGK3) in colon cancer. Methods: SP immunohistochemical method was used to detect the expression of SGK3 in 70 cases of colon cancer tissues and 30 cases of adjacent normal tissues; And the relationships between SGK3 expression and pathological features of colon cancer were also analyzed. Results: The SGK3 expression in colon cancer was 74.3% (52/70), which was significantly higher than that in adjacent normal tissue (16.7%, 5/30) (P<0.05). In colon cancer, the SGK3 expression was related to TNM stage, depth of invasion and lymph node metastasis (P<0.05); but was irrelevant to age, gender, tumor size and histopathological differentiation (P>0.05). Conclusions: High expression of SGK3 may participate the development of colon cancer, and maybe related with the poor prognosis of colon cancer.

Objective: To investigate the expression and clinical significance of Six1 and E-cad in colon cancer. Methods: SP immunohistochemical method was used to detect Six1 and E-cad expression in 70 cases of colon cancer and 30 cases of adjacent normal tissue; and the correlations between Six1, E-cad and the clinical pathological characteristics of colon cancer were also analyzed. Results: The positive expression rate of Six1 in colon cancer was obviously higher than adjacent normal tissue, but the positive expression rate of E-cad was obviously lower (P<0.01). The Six1 and E-cad expression in colon cancer was not related to sex, age, size of tumour and differentiation degree (P＞0.05); But related to TNM stage and infiltration depth (P＜0.05). The expression of Six1 in colon cancer was negative correlated to E-cad expression (r=-0.480, P＜0.01). Conclusions: E-cad and Six1 maybe involved in development of colon cancer together; Moreover, E-cad and Six1 expression is closely related to poor prognosis of colon cancer.