Objective: To investigate the relationships between vascular endothelial function, serum homocysteine (Hcy) level and state of coronary heart disease in elderly patients. Methods: 577 elderly coronary heart disease patients were divided into the following groups according to NYHA grade: group Ⅰ(213 patients with cardiac function grade Ⅰ), group Ⅱ (201 patients with cardiac function Ⅱ) and group Ⅲ~Ⅳ (163 patients with cardiac function grade Ⅲ~Ⅳ). 100 healthy elderly persons in the same period were selected as control. The carotid intima-media thickness (IMTc), brachial artery blood flow mediated diastolic function (FMD), serum Hcy level, serum high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) lever of all the human subjects were detected respectively. Results: The IMTc and Hcy of patients in 3 coronary heart disease groups were obviously higher than control, the FMD was obviously lower (P<0.05). There was no significantly statistical differences in serum HDL-C and LDL-C level between all the subjects (P>0.05). In coronary heart disease groups, the IMTc and Hcy gradually increased, FMD gradually decreased with increasing of cardiac function classification (P<0.05). Conclusions: The severity of coronary heart disease in elderly patients is related to vascular endothelial function and serum Hcy level.

Objective: To study the effects of adjuvant treating chronic heart failure with rosuvastatin on cardiac function, inflammatory response and oxidative stress. Methods: 90 chronic heart failure patients were randomly divided into study group (45 cases) and control group (45 cases). The patients in control group were given routine treatments for 3 months; On the basis of routine treatments, the patients in study group were also given rosuvastatin for 3 months. The cardiac function indexes [left ventricular end-diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and A E peak velocity ratio (E/A value)], serum inflammatory factors level [hypersensitive C-reactive protein (hs-CRP),interleukin 6 (IL - 6), tumor necrosis factor alpha (TNF-α)] and plasma oxidative stress indexes [peroxidase (MPO),superoxide dismutase (SOD), malondialdehyde (MDA)] of patients in 2 groups were compared. Results: After treatment, the LVEF, E/A and SOD of patients in study group were obviously higher than control group (P<0.05); the LVEDD, LVESD, hs-CRP, IL-6, TNF-α, MPO and MDA were obviously lower than control group (P<0.05). Conclusions: Adjuvant treating chronic heart failure with rosuvastatin on the basis of routine treatments can get definite curative effects, which can improve the cardiac function, reduce inflammatory response and oxidative stress effectively.