Objective To study the features of clinical, dermoscopic and pathological of Seborrheic Keratosis and analyze their correlation. Methods Sixty-one patients with Seborrheic Keratosis diagnosed by histomathological examination and dermoscopy, who were admitted to the Affiliated Hospital of Chengde Medical University from March 2017 to December 2019, were selected to analyze the relationship between different clinical features, dermoscopy findings and pathological features of skin lesions. Results Under the dermoscope of fissures/ brain pattern appearance, comedo-like openings,milia-like cysts, the proportion of clinical papule, plaque and nodule was higher than that of macule, patch and verruca/papilla, and the differences were statistically significant (P<0.05). There were positive correlation between fissures/brain pattern appearance and hyperkeratosis and acanthosis (P<0.05). There were positive correlations between comedo-like openings, punctiform/hairpin blood vessels, milia-like cysts and acanthosis (P<0.05). Conclusion The diagnostic rate of seborrheic keratosis could be improved by the combination of dermoscopic examination and clinical features, and the accurate rate of diagnose of dermoscopy and pathology is highly consistent.