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REGULATORY EFFECTS OF SERICIN ON LIVER IR IN TYPE 2 DIABETIC RATS
LIU Dong-hui, LI Dong-zhe, ZHANG Xiang-yun, et al
Objective: To investigate th regulatory effects of sericin on liver insulin receptor (IR) in type 2 diabetic rats.
Methods: Thirty-six SPF male rats were randomly divided into three groups (normal group, model group and experimental group), with 12 rats in each group. The rat model of type 2 diabetes mellitus was induced by high-fat, high-sugar feeding and intraperitoneal injection of streptozotocin. After modeling, the rats were given sericin by gavaging for 35 days in the experimental group. The glucose oxidase method was used to detect the fasting blood glucose of rats in each group. Real Time Q-PCR was used to detect the expression of IR mRNA in liver.
Results: Compared with the rats in model group, the blood glucose of rats in experimental group was significantly reduced, and the expression of liver IR of rats in experimental group increased significantly (P< 0.05).
Conclusions: Sericin may enhance the transduction effects of insulin signal by up regulating the expression of IR in liver of diabetes mellitus rats, thus reducing the blood glucose.
2018, 35 (5):
361-363.
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