Objective: To explore the treatment effects of labetalol hydrochloride combined with folic acid on early-onset preeclampsia and the effects on maternal-infant outcomes. Methods: Ninety-six patients with early-onset preeclampsia were randomly divided into study group and control group with 48 cases in each group. The patients in control group were treated with conventional treatment and folic acid; On the basis of the control group, the patients in study group were also give labetalol hydrochloride. The blood pressure [systolic blood pressure (SBP), diastolic blood pressure (DBP)], uterine hemodynamics indexes [pulsatility index (PI), resistance index (RI)] before and 1week after treatment, as well as the maternal-infant outcomes (natural delivery, postpartum hemorrhage, placental abruption, neonatal asphyxia, neonatal Apgar score) of patients in 2 groups were compared. Results: 1 week after treatment, the SBP, DBP, PI and RI of patients in 2 groups were significantly decreased compared with those before treatment (P<0.05); And the above indexes of patients in study group after treatment were significantly lower than those in control group after treatment (P<0.05). There were no significant statistical significances about the incidence rates of postpartum hemorrhage, placental abruption and neonatal asphyxia between the two groups (P>0.05). The natural delivery rate and neonatal Apgar score of patients in study group were significantly higher than those in control group (P<0.05). Conclusions: Labetalol hydrochloride combined with folic acid has better effects on treating early-onset preeclampsia, and it can control blood pressure, improve uterine blood supply and neonatal physical condition at birth effectively.