Objective: To analyze the relationships between apolipoprotein B/A1, glycosylated hemoglobin (HbA1c) level and venous thrombolytic outcome in acute cerebral infarction patients. Methods: 76 acute cerebral infarction patients were all treated with recombinant tissue plasminogen activator (rt-PA) venous thrombolysis, and the patients were divided into ineffective group (n=27) and effective group (n=49) according to improvement of NIHSS score before and after thrombolysis. The blood glucose, blood lipid, HbA1c and other indicators of all the patients were detected. Results: The HbA1c, ApoB and ApoB/A1 of patients in effective group were significantly lower than ineffective group, the ApoA1 was significantly higher (P<0.05). Logistic regression analysis showed that age, HbA1c and ApoB/A1 were independent risk factors for thrombolytic outcome (P<0.05). Conclusions: ApoB/A1 and HbA1c may has certain predicting value for thrombolytic outcome in acute cerebral infarction patients at early stage.

ObjectiveTo investigate the effects of type H hypertension on prognosis of intravenous thrombolysis in patients with acute cerebral infarction.Methods182 cases of acute cerebral infarction patients receiving intravenous thrombolysis with at-PA were divided into type H hypertension+cerebral infarction group (group A), hypertension+cerebral infarction group (group B), hyperhomocysteinemia+cerebral infarction group (group C) and cerebral infarction group without HHcy and hypertension (group D). The blood pressure, serum Hcy level and prognosis of patients in 4 groups were compared; And the influencing factors of poor prognosis after thrombolytic therapy were also analyzed.ResultsThe systolic pressure, serum Hcy level of patients in group A were obviously higher than group B, C, D (P<0.05). Compared with other 3 groups, the incidence of poor prognosis of group A was the highest (P<0.05). Logistic regression analysis showed that age, Hcy and systolic pressure are independent risk factors of recent poor prognosis of intravenous thrombolysis after acute cerebral infarction.ConclusionsType H hypertension is an important risk factor for the prognosis of intravenous thrombolysis in patients with acute cerebral infarction.