Objective: To study the expression and significance of migration induced protein-7 (MIG-7) and matrix metalloproteinase-2 (MMP-2) in colon cancer. Methods: Immunohistochemical staining was used to detect the expression of MIG-7 and MMP-2 in 70 cases of colon cancer tissues and corresponding adjacent normal tissues. The relationships between MIG-7, MMP-2 and the clinicopathological characteristics of colon cancer, and the correlations between MIG-7 and MMP-2 in colon cancer tissues were also analyzed. Results: The positive expression rate of MIG-7 and MMP-2 in 70 cases of colon cancer tissues were 61.43% and 70.00% respectively, which were all singnificantly higher than adjacent normal tissues (P˂0.05). In colon cancer, the expression of MIG-7 and MMP-2 were related to differentiation and lymph node metastasis (P˂0.05); but irrelevant to sex, age and tumor size (P>0.05). In colon cancer, the expression of MIG-7 was positively correlated with MMP-2 (r=0.506,P˂0.05). Conduidons: MIG-7 and MMP-2 may participate in the growth and metastasis of colon cancer together.