Objective: To investigate the production of extended-spectrum beta-Lactamases (ESBLs) and carbapenemases (KPC) in Klebsiella pneumoniae isolated from tumor patients, and analyze the drug resistance of corresponding strains to common antibiotics. Methods: The ESBLs and KPC production of 306 strains Klebsiella pneumoniae from tumor patients in our hospital from 2017.9 to 2018.8 were detected, and the drug resistance of corresponding strains to common antibiotics were compared by in vitro drug susceptibility. Results: The detection rate of ESBLs and KPC were 73.53% (225/306) and 10.46% (32/306) respectively. The resistance of ESBLs-producing strains to various antibiotics was significantly higher than that of non-ESBLs-producing strains (P<0.05). The carbapenemase-producing Klebsiella pneumoniae (CRKpn) showed high level of resistance to all the drugs tested, and the resistance rate of most of the drugs reached 100.00%. Conclusions: ESBLs and KPC produced by Klebsiella pneumoniae infected by tumor patients are serious in our hospital, and the drug resistance rate of the corresponding strains is high. It is necessary to strengthen the control of infection, standardize the application of antibiotics, and prevent further increasing or diffusion of ESBLs-producing strains and CRKpn.