Objective To systematically evaluate the related factors affecting the prognosis of stroke patients with dysphagia, so as to provide evidence for the rehabilitation guidance of clinical prognosis of stroke patients with dysphagia. Methods The related studies on the prognostic factors of dysphagia in stroke were searched in the databases of CNKI, WanFang, Cochrane Library, PubMed and Web of Science. The search time was limited from January 1, 2010 to May 1, 2020. Meta analysis was performed by software RevMan5.3. Results A total of 11 articles were included. The results of Meta analysis showed that age≥70 years old (OR=0.16, 95%CI), cognitive impairment (OR=0.11, 95%CI), sensory aphasia (OR=0.18, 95%CI), dysphagia degree (OR=0.11, 95%CI), rehabilitation intervention time (OR=-6.10). 95%CI (-6.54), brainstem damage (OR=0.14, 95%CI), BI<60 (OR=0.42, 95%CI) and NIHSS score≥12 (OR=0.20, 95%CI) were the factors affecting the prognosis of dysphagia in stroke. Conclusion The prognostic effect of stroke patients with dysphagia is affected by many factors. Targeted preventive intervention measures should be given to the controllable factors in order to speed up the rehabilitation process, lighten the burden and promote the patients to return to society as soon as possible.