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CORRELATIONS BETWEEN SERUM CYSTATIN C LEVEL AND EGFR IN PATIENTS WITH EARLY DIABETIC NEPHROPATHY
CHEN Hai-lan, GUO Hai-xia, GAO Yu
Objective: To investigate the correlations between serum cystatin C level and estimated glomerular filtration rate (eGFR) in patients with early diabetic nephropathy.
Methods: 60 patients with early diabetic nephropathy were divided into group A (n=33) and group B (n=27) according to serum cystatin C level; 70 health examination people in our hospital during the same period were selected as group C. The serum cystatin C level, serum creatinine of all the subjects were detected and the eGFR was calculated using MDRD formula. Linear correlation analysis was used to analyze the correlations between serum cystatin C level and eGFR in patients with early diabetic nephropathy.
Results: The serum cystatin C level of early diabetic nephropathy patients in group A and group B were all significantly higher than group C, while the eGFR were significantly lower (P<0.05). The serum cystatin C level of early diabetic nephropathy patients was negatively correlated with eGFR (r=-0.7193, P<0.05).
Conclusions: The serum cystatin C level is negatively correlated with eGFR in patients with early diabetic nephropathy, which may be a predictor of early diagnosis of diabetic nephropathy.
2019, 36 (3):
211-213.
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