Objective: To investigate the production of extended-spectrum beta-Lactamases (ESBLs) and carbapenemases (KPC) in Klebsiella pneumoniae isolated from tumor patients, and analyze the drug resistance of corresponding strains to common antibiotics. Methods: The ESBLs and KPC production of 306 strains Klebsiella pneumoniae from tumor patients in our hospital from 2017.9 to 2018.8 were detected, and the drug resistance of corresponding strains to common antibiotics were compared by in vitro drug susceptibility. Results: The detection rate of ESBLs and KPC were 73.53% (225/306) and 10.46% (32/306) respectively. The resistance of ESBLs-producing strains to various antibiotics was significantly higher than that of non-ESBLs-producing strains (P<0.05). The carbapenemase-producing Klebsiella pneumoniae (CRKpn) showed high level of resistance to all the drugs tested, and the resistance rate of most of the drugs reached 100.00%. Conclusions: ESBLs and KPC produced by Klebsiella pneumoniae infected by tumor patients are serious in our hospital, and the drug resistance rate of the corresponding strains is high. It is necessary to strengthen the control of infection, standardize the application of antibiotics, and prevent further increasing or diffusion of ESBLs-producing strains and CRKpn.

Objective: To probe the ureaplasma urealyticum infection (UU) in pregnancy and analyze the influences of UU infection on pregnancy outcome. Methods: The UU infection of 286 early and mid pregnant women in our hospital, as well as 150 non pregnant women of childbearing age were detected and the pregnancy outcome of all the pregnant women were tracked. The UU positive pregnant women were divided into antibiotics treatment group and non antibiotics treatment group according to the use of antibiotics; the UU infection were rechecked after treatment, and the UU cure rate and normal parturition rate were recorded. Results: The positive rate of UU infection in 286 pregnant women was 39.16% (112/286), which was obviously higher than non pregnant women of childbearing age (28.67%, P<0.05). The adverse pregnancy outcomes of UU infection group was 53.57% (60/112), which was obviously higher than UU negative group (26.44%, P<0.05). The UU cure rate and normal parturition rate of antibiotics treatment group were respectively 88.61% (70/79) and 62.02% (49/79), which were obviously higher than non antibiotics treatment group (12.12%, 9.09%, P<0.05). Conclusions: The UU infection rate of pregnant women is obviously higher than non pregnant women of childbearing, and UU infection is closely related to adverse pregnancy outcomes. Pregnant women with UU infection should be treated with sensitive antibiotics as soon as possible in order to reduce the impacts of UU infection on pregnancy outcome.