ObjectiveTo observe the effects of remifentanil combined fentanyl on cardiovascular response of endotracheal intubation during general anesthesia.Methods60 elective surgery patients were randomly divided into fentanyl (F) group, remifentanil combined fentanyl (RF) group and remifentanil (R) group with 20 patients in each group. The systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) at 5min before intubation (T0), immediate intubation (T1), 1min after intubation (T2), 3min after intubation (T3) and 5min after intubation (T4) of patients in 3 groups were respectively recorded. The complications, such as bradycardia, cough and muscle rigidity were also observed.ResultsAt T2 and T3 time point, the SBP, DBP, MAP of patients in RF group were all obviously lower than F group and R group (P<0.05). At T1 time point, the HR of 2 patients in R group were lower than 45/min and were treated with intravenous atropine; the SPB of 1 patient was lower than 90mmHg and treated with intravenous ephedrine. 2 patients in F group suffered cough.ConclusionsThe stress response of endotracheal intubation was light and hemodynamic indexes were stable in patients with low dose of remifentanil combined fentanyl.