Objective: To investigate the clinical effects of enhanced heart rate control in the treatment of chronic heart failure (CHF). Methods: 150 cases of CHF patients were randomly divided into treatment group and control group with 75 patients in each group. The patients in control group were treated with conventional medicine; the resting heart rate of patients in treatment group was controlled by metoprolol tartrate on the basis of conventional medicine, and the target heart rate was 50-60/min. The curative effects of 2 groups were evaluated after 12 months’ treatment; as well as the heart rate, left ventricular myocardial weight (LVMV), left ventricular ejection fraction (LVEF), ∆T% and adverse reactions of patients in 2 groups were observed. Results: The total effective rate of treatment group was 94.7% (71/75) after 12 months’ treatment, which was obviously higher than control group (P<0.05). The heart rate of patients in 2 groups all decreased obviously after treatment; Moreover, the heart rate of patients in treatment group was obviously lower than control group (P<0.05). After treatment, the LVMV, LVEF and ∆T% of patients in 2 group improved significantly; And the improvement of treatment group was significantly better than that control group (P<0.05). There was no significant difference about the incidence of adverse reactions between treatment group and control group (6.7% vs 4.0%, P>0.05). Conclusions: Heart rate control in treatment of CHF can significantly improve the curative effects and improve the cardiac function of CHF patients.