Objective: To investigate the effects of delivery modes on mother-fetus outcome in scarred uterus with subsequent pregnancy after cesarean section. Methods: 100 scarred uterus pregnant women with subsequent pregnancy after cesarean section were divided into observation group (vaginal trail delivery, n=48) and control group (cesarean section delivery, n=52) according to delivery modes. The clinical indexes, maternal complications, neonatal complications were compared between the two groups. Results: Compared with control group, the postpartum 24h bleeding volume of observation group was less, the hospital stays of observation group were shorter, the 1min Apgar score of observation group was higher (P<0.05). The incidence of pelvic adhesion, puerperalism, neonatal pneumonia in observation group were obviously lower than that in control group (P<0.05). There was no statistical difference in the incidence of neonatal asphyxia and pathologic jaundice between the two groups (P>0.05). Conclusions: As for scarred uterus pregnant women with subsequent pregnancy after cesarean section having vaginal delivery indicators, vaginal delivery can decrease postpartum 24h bleeding volume, reduce the incidence of maternal complications and neonatal pneumonia, improve mother-fetus outcome.