Objective To investigate the relationship between the levels of growth differentiation factor-15 (GDF-15), vascular endothelial growth factor (VEGF), and CXC chemokine receptor 4 (CXCR4) and in-stent restenosis (ISR) in patients with coronary heart disease after percutaneous coronary intervention (PCI). Methods A total of 118 patients with coronary heart disease admitted to Henan Provincial Rongjun Hospital from March 2021 to June 2022 were selected and all received PCI. They were divided into ISR group (24 cases) and non-ISR group (94 cases) according to whether ISR occurred after PCI. Enzyme-linked immunosorbent assay was used to measure GDF-15 and CXCR4, and double antibody sandwich-enzyme-linked immunosorbent assay was used to measure VEGF. The correlation and predictive value of serum GDF-15, VEGF, CXCR4 and ISR in patients with coronary heart disease after PCI were analyzed. Results The number of coronary lesions and the number of stents implanted in the ISR group were higher than those in the non-ISR group, and the length of coronary lesions was longer than that in the non-ISR group. The preoperative Gensini score, left ventricular ejection fraction (LVEF), D-dimer (D-D), fibrinogen (FIB), GDF-15, and VEGF were higher than those in the non-ISR group, while CXCR4 was lower than that in the non-ISR group, and the differences were statistically significant (P<0.05). Increased levels of FIB, GDF-15, VEGF, and decreased levels of CXCR4 were independent risk factors for the development of ISR after PCI, and the differences were statistically significant (P<0.05). After further adjusting for the influence of FIB, GDF-15, VEGF, and CXCR4 remained associated with the development of ISR after PCI. The AUC of the combined prediction of serum GDF-15, VEGF, and CXCR4 for predicting ISR after PCI was significantly greater than that of each individual predictor, and the differences were statistically significant (P<0.05). Conclusion Serum GDF-15, VEGF and CXCR4 levels are significantly correlated with ISR in patients with coronary heart disease after PCI. All of them have predictive value for ISR, and combined detection can provide more reliable data support for clinical practice.

Objective To investigate the clinical efficacy of trigger point therapy combined with core stability training in the treatment of chronic nonspecific low back pain (CLBP). Methods Seventy-two patients with CLBP were randomly divided into control group and experimental group with 36 cases in each group. Patients in control group were treated with TDP magic lamp irradiation, The experimental group received trigger point therapy combined with core stability training on the basis of the control group, 5 times a week for 2 weeks. The total effective rate of the 2 groups was evaluated after treatment, and the visual analogue scale (VAS) and Oswestry Disability Index (ODI) scores were evaluated before and after treatment. One month after treatment, VAS score and ODI score were followed up between the two groups, and the differences in the above evaluation contents were compared. Results Before treatment, there was no significant difference in VAS score and ODI score between the two groups (P>0.05). After treatment, there were significant differences in the total effective rate, VAS score and ODI score between the two groups (P<0.05). At 1 month follow-up after treatment, the VAS score and ODI score in the group were significantly different from those before and after treatment (P<0.05), and the VAS score and ODI score were significantly different between groups (P<0.05). Conclusion Trigger point therapy combined with core stability training can reduce pain and improve lumbar function of patients with significant clinical efficacy.