Objective To investigate the effect of core stability training in the treatment of lumbar degenerative diseases after percutaneous endoscopic discectomy. Methods A total of 60 patients with LDD, who were admitted to the spinal surgery department of hospital and received PELD treatment from October 2019 to December 2019, were selected as study subjects by the convenience sampling method. According to the methods of rehabilitation, 30 patients who received core stabilization training nursing after PELD surgery as the observation group and 30 patients who received routine nursing after PELD surgery as the control group. VAS and ODI scores of the two groups were compared before surgery, 1 week after surgery and 1 month after surgery, respectively. Results The VAS score and ODI score of the observation group were significantly lower than that of the control group (P<0.05). Conclusion The core stability training method can reduce the postoperative pain of LDD patients, improve the clinical efficacy, and is worthy to be clinically popularized.