|
CHANGES AND SIGNIFICANCE OF SERUM TNF-Α, VEGF AND ET-1 LEVEL IN PATIENTS WITH HYPERTENSIVE CEREBRAL HEMORRHAGE
LIU Si-yang, WU Jian-long, QIAO Jian-yong, et al
Objective:To investigate the changes and clinical significance of serum tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) level in patients with hypertensive cerebral hemorrhage (HICH). Methods:ELISA was used to detect the serum TNF-α, VEGF and ET-1 level of HICH patients and healthy controls; And the serum TNF-α, VEGF and ET-1 level of HICH patients with different GCS scores were analyzed. Results:The serum TNF-α, VEGF and ET-1 level of HICH patients were significantly higher than healthy controls (P<0.05). Along with decreasing of GCS score in HICH patients, the serum TNF-α, VEGF and ET-1 level gradually increased (P<0.05). Conclusions:Detection of serum TNF-α, VEGF and ET-1 level play important role in diagnosis and prognosis of HICH patients.
2018, 35 (4):
296-298.
|
|