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EXPRESSION AND SIGNIFICANCE OF APOPTOSIS RELATED FACTORS CCAR1 AND PAR-4 IN GASTRIC ADENOCARCINOMA
LV Rong-rong, QI Jie-min, CHEN Long
Objective: To investigate the expression and significance of cell division cycle and apoptosis regulator protein1 (CCAR1) and prostate apoptosis response-4 gene (Par-4) protein in gastric adenocarcinoma.
Methods: SP immunohistochemical staining was used to detect the expression of CCAR1 and Par-4 in 60 gastric adenocarcinoma tissues and 40 paracancerous normal gastric mucosa tissues. The relationships between CCAR1, Par-4 and clinicopathological parameters of gastric adenocarcinoma, as well as the correlation of CCAR1 and Par-4 in gastric adenocarcinoma were analyzed.
Results: The positive expression rate of CCAR1 protein in gastric adenocarcinoma tissues was significantly higher, while the Par-4 protein was significantly lower than that of normal gastric mucosa (P<0.05). The CCAR1 protein expression in gastric adenocarcinoma was related to differentiation degree (P<0.05); The expression of par-4 protein was related to differentiation degree, TNM stage and lymph node metastasisa (P<0.05). Spearman correlation analysis showed that no correlation between the expression of CCAR1 protein and Par-4 protein in gastric adenocarcinoma (r=-0.08, P>0.05).
Conclusions: Par-4 and CCAR1 involve in the occurrence and progression of gastric adenocarcinoma together, but they may be regulated by different mechanisms.
2018, 35 (6):
451-454.
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