Objective To evaluate the risk factors of hepatic encephalopathy in patients with cirrhosis. Methods Retrieve database both at home and abroad, collecting the relevant risk factors in patients with cirrhosis of the liver encephalopathy of case-control study, retrieval time limit are built from library to December 31, 2020, after finishing the document screening and quality evaluation software application Revman5.4 meta-analysis. Results A total of 9 papers with 1569 patients were included in this study, involving 10 risk factors, of which high heterogeneity in serum albumin and blood creatinine was not subjected to Meta-analysis.Serum ammonia, infection, upper gastrointestinal hemorrhage, ascites, serum total bilirubin, prothrombin time, urea nitrogen and serum natrium are risk factors for hepatic encephalopathy in patients with cirrhosis (P<0.05). Conclusion Elevated serum ammonia level, infected, upper gastrointestinal bleeding, ascites, serum total bilirubin level increased, prothrombin time prolonged, serum sodium level decreased and blood urea nitrogen increased are risk factors for hepatic encephalopathy in patients with cirrhosis, serum albumin levels and serum creatinine levels were uncertain.