Objective To analyze the diagnostic value of carotid cerebral integrated ultrasound (Transcranial Doppler and carotid artery ultrasound) in detecting the degree of intracranial external arterial stenosis in the diagnosis of coronary artery stenosis. Methods A total of 186 patients who underwent coronary angiography in the Affiliated Hospital of Chengde Medical University from January 2019 to December 2020 were selected as the study subjects, and were divided into two groups: the coronary heart disease group (98 cases) and the non coronary heart disease group (88 cases). The patients in the coronary heart disease group were then divided into a single vessel disease group (32 cases) and a multi vessel disease group (66 cases) based on the main coronary artery disease and the number of affected branches. Transcranial Doppler (TCD) and carotid artery ultrasound were performed in both groups to measure carotid intima-media thickness (IMT), plaque thickness, and number, and calculate plaque scores. In addition, carotid and intracranial artery stenosis were counted in both groups, and the risk factors affecting the degree of coronary atherosclerosis were analyzed by logistic regression analysis. Results The body mass index, smoking, hypertension, hyperlipidemia, and serum hs-CRP levels in the coronary heart disease group were significantly higher than those in the non coronary heart disease group. Carotid artery ultrasound examination results showed that the IMT and plaque score in patients with coronary heart disease were higher than those in patients without coronary heart disease. The IMT and plaque score in the subgroup of multi vessel disease in the coronary heart disease group were higher than those in the single vessel disease group. The severity of carotid stenosis in patients with coronary heart disease was significantly higher than those in the non coronary heart disease group. The results of TCD examination showed that the severity of intracranial artery stenosis in patients with coronary heart disease was significantly higher than that in patients without coronary heart disease. The more severe the stenosis of intracranial and internal carotid arteries was, the higher the degree of coronary artery disease was, and the more branches of diseased vessels were. Multivariate logistic regression analysis showed that hypertension, hyperlipidemia, internal carotid artery stenosis , intracranial artery stenosis, body mass index, hs-CRP are independent risk factors that affecting the degree of coronary atherosclerosis. Conclusion Combined carotid and cerebral ultrasound can effectively diagnose the degree of intracranial and external vascular stenosis, and there is a significant positive correlation between the degree of intracranial and external arterial stenosis and the degree of coronary artery stenosis. The degree of intracranial and carotid artery stenosis are independent risk factors that affect the degree of coronary artery stenosis.