Objective To investigate the expression of serum adiponectin (ADPN), irregular chemokine (FKN) and Gremlin in diabetic nephropathy (DN) patients and their correlation with renal function. Methods One hundred cases of DN patients admitted to First Affiliated Hospital of Henan University of Science and Technology from June 2020 to June 2022 were retrospectively selected as the observation group, and another 100 cases of simple diabetes mellitus (DM) patients in the same period were selected as the control group. The serum levels of ADPN, FKN and Gremlin were compared between the two groups, and the renal function indexes [cystatin C (CysC), creatinine (SCr) and urinary protein excretion rate (UAER)] were compared between the two groups. The correlation between serum indexes and renal function indexes was analyzed, and the diagnostic value of serum indexes in DN was analyzed by ROC. Results Serum levels of ADPN, FKN, Gremlin, CysC, SCr and UAER in observation group were higher than those in control group (P < 0.05). Serum levels of ADPN, FKN and Gremlin were positively correlated with renal function indexes CysC, SCr and UAER, and the AUC of all serum indexes in combined diagnosis of DN was 0.885, the best diagnostic sensitivity and specificity were 90.00% and 85.00%, respectively, and the Yoden index was 0.750. Conclusion ADPN, FKN and Gremlin are up-regulated in the serum of patients with DN, and the levels of each indicator are positively correlated with the levels of renal function indicators. Combined detection has certain diagnostic value for DN, and can be used as an effective indicator for clinical diagnosis of DN and evaluation of renal function.

Objective To observe the clinical efficacy of different root canal sealants in one-time root canal therapy. Methods From January 2018 to January 2019, 80 patients (100 affected teeth) who received one-time root canal treatment were selected. According to the group of odd-even number, single number was divided into control group and double number into experimental group. AH Plus paste was used in the control group and iRoot SP paste was used in the experimental group. VAS scores changes, root filling quality, acute inflammatory response rate within 1 week after root filling and efficacy after 1 year were compared between the two groups. Results After 3 and 7 days of treatment,VAS score of experimental group was lower than that of control group(P<0.05). After root filling, the experimental group was higher than the control group(P<0.05).The rate of acute inflammatory response in experimental group was lower than that in control group within 1 week after treatment(P<0.05). The comparison of treatment success rated after 1 year showed that the experimental group was higher than the control group(P<0.05). Conclusion The application of iRoot SP paste in one-time root canal therapy can not only reduce the acute inflammatory reaction after treatment, reduce pain, but also improve the quality of root filling and the success rate of treatment, which is worth popularizing.