Objective: To explore the effects of chronic total occlusion lesions (CTO) with different coronary artery counts on myocardial function and ventricular remodeling. Methods: 124 CTO patients were divided into single occlusion group (n=77), double occlusion group (n=25) and multiple occlusion group (n=22) according to occlusion counts. The myocardial function indexes [cardiac troponin I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase (CK), creatine kinase isoenzyme (CK-MB)] and ventricular remodeling indexes [left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF)] of patients in 3 groups were compared. Results: The level of cTnI, NT-proBNP, CK, CK-MB, LVEDD and LVESD showed that multiple occlusion group>double occlusion group>single occlusion group (P<0.05). The LVEF showed that multiple occlusion group<double occlusion group<single occlusion group (P<0.05). Conclusions: The myocardial function and ventricular remodeling in CTO patients are associated with CTO occlusion counts. The more occlusion counts, the worse myocardial function and the more serious ventricular remodeling in CTO patients.