Objective: To explore the application value of shear-wave elastography (SWE) combined with strain elastography (SE) in the diagnosis of breast lesions. Methods: A total of 76 patients (119 cases) with breast lesions were enrolled in this study,SE, SWE and their combination were used for diagnosis. The diagnostic value of SE, SWE and their combination were compared by taking pathological examination results as gold standard. Results: The sensitivity, specificity and accuracy of SE for diagnosis of malignant breast tumors were 80.95%, 83.12% and 82.35% respectively. The above indexes of SWE were 76.19%, 87.01% and 83.19% respectively. The above indexes of SE combined with SWE were 95.24%, 96.10% and 95.80% respectively. The sensitivity, specificity and accuracy of their combination diagnosis were significantly higher than those of SE and SWE alone (P<0.05). Conclusions: The combination of SE and SWE can improve diagnostic sensitivity, specificity and accuracy for malignant breast tumor, which can provide reference for early diagnosis and choice of treatment plan.