Objective: To investigate the predictive value of the changes of coagulation and fibrinolysis function indexes in patients with lung cancer before and after radiotherapy for the short-term efficacy and survival period. Methods: 82 patients with lung cancer were all treated with IMRT, and the efficacy was evaluated after 3 months. The changes of D-dimer, fibrinogen (FIB), fibrin degradation products (FDP) and platelet (PLT) before and after radiotherapy were compared; And the relationships between the above indexes and patients' short-term efficacy, survival period were analyzed. Results: In 82 patients, 42 patients with partial remission (PR) after 3 months, 21 patients was stable (SD) and 19 patients was progression (PD). For PR patients (effective group), the D-dimer, FDP and PLT levle after radiotherapy were significantly lower than those before radiotherapy (P<0.05). For PD+SD patients (ineffective group), the D-dimer, FIB and FDP levle after radiotherapy were significantly higher than those before radiotherapy, but the PLT level was significantly lower (P<0.05). After radiotherapy, the D-dimer and FIB level of patients in effective group were significantly lower than ineffective group (P<0.05). The median survival period of 82 patients was (19.60±8.92) months. Before radiotherapy, the D-dimer, FIB, FDP of patients in good prognosis group (survival period>19 months) were significantly lower than poor prognosis group (survival period<19 months,P<0.05); There has no significant difference in PLT between good prognosis group and poor prognosis group (P>0.05). Conclusions: Monitoring the changes of D-dimer, FIB, FDP and PLT before and after radiotherapy in patients with lung cancer is helpful to evaluate the short-term efficacy and survival period.