Objective: To investigate the diagnostic value of plasma D-dimmer level combined with Wells score for chronic heart failure (CHF) suspected with lower limb deep venous thrombosis (LDVT). Methods: The clinical data of 100 CHF patients suspected with LDVT were retrospectively analyzed. The patients were diagnosed respectively by plasma D-dimmer level, Wells score and combination of the two methods; The results were compared with the diagnostic results of color Doppler at the same time. Results: The sensitivity, specificity and accuracy of D-dimmer for diagnosing LDVT was 84.71%, 40.00% and 78.00% respectively. The consistency between D-dimmer and color Doppler was poor (Kappa=0.223). The sensitivity, specificity and accuracy of Wells score for diagnosing LDVT was 94.12%, 60.00% and 89.00% respectively. The consistency between Wells score and color Doppler was general (Kappa=0.556). The sensitivity, specificity and accuracy of D-dimmer combined with Wells score for diagnosing LDVT was 98.82%, 73.33% and 95.00% respectively. The consistency between combination of above two methods and color Doppler was better (Kappa=0.786). Conclusions: D-dimmer combined with Wells score has higher sensitivity and accuracy for diagnosing CHF suspected with LDVT, which is simple and rapid, and has the value of clinical promotion.