Objective To explore the safety test and clinical efficacy evaluation of 3D printing image contrast technology model in Sanders type II (sanders II) calcaneal fractures. Methods Retrospective analysis of 46 cases of sandersII calcaneal fracture treated in Affiliated Hospital of Chengde Medical University from May 2014 to October 2021 was made. According to the preoperative plan, patients were divided into mirror image technique group (23 cases) and radiology technique group (23 cases), the measured data of scaphoid bone and fifth metatarsal bone of the affected side and the healthy side were compared by mirror image. The clinical effects were evaluated by preoperative, perioperative and follow-up indexes. Results The measured data of scaphoid bone and fifth metatarsal bone of the affected side and the contralateral side were compared in the mirror image technique group,there was no significant difference between the two groups (P>0.05), so it was safe to use the mirror image technique in preoperative planning. There were significant differences in pre-operative planning related cost, pre-operative planning related time and fracture reduction time between the two groups (P>0.05). All patients were followed up for 9-15 months with an average of (12.48±2.26) months. There was a significant difference in fracture healing rate between the two groups (P>0.05), and there was no significant difference in Maryland foot function between the two groups (P>0.05). Conclusion The application of 3D printing mirror image contrast technique in sandersII type calcaneal fracture is safe and reliable, and the clinical effect is definite, but it will increase the economic and time burden of patients.

Objective To compare the effects of DSA-guided Fogarty balloon catheter removal and incision exploration in the treatment of arterial crisis combined with thrombosis. Methods Analysis rstrospectively the clinical data of 35 cases who had vascular crisis after replantation of severed limbs and diagnosed with combined thrombosis by high-frequency ultrasound from September 2012 to May 2020 in the Affiliated Hospital of Chengde Medical University. According to the surgical method, the cases divided into minimally invasive group (fogarty balloon catheter thrombectomy under DSA guidance, 12 cases) and open group (incision and exploratory surgery, 23 cases). A comparative study of various indicators before, during and after the operation. Results There was no statistically significant difference in general information between the two groups at admission (P>0.05), and they were comparable; the time to vascular repatency, intraoperative operation time, and intraoperative blood loss in the minimally invasive group were significantly lower than those in the open group (P<0.05); the postoperative re-embolization rate and postoperative amputation rate of the minimally invasive group were significantly lower than those of the open group (P<0.05); there was no significant difference between the two groups in the rate of good limb function at 9 months postoperative follow-up (P>0.05); the hospitalization medical expenses open group was significantly lower than the minimally invasive group (P>0.05). Conclusion DSA-guided Fogarty balloon catheter removal for arterial crisis combined with thrombosis can avoid secondary damage to the repair area of the broken end, with low incidence of complications and definite early curative effect, but will increase medical costs.

Objective To explore the effect of berberine hydrochloride on human CXC chemokine ligand 16 (CXCL16) and interleukin 33 (interleukin-33, IL-33) in patients with acute cerebral infarction. Methods 118 patients with acute cerebral infarction were divided into berberine group and control group (59 cases each) according to random number table. The control group was given basic treatments such as nutritional nerves, stable plaque, and improved circulation. The berberine group was supplemented with berberine hydrochloride tablets orally 0.5g twice a day for 2 weeks. Serum CXCL16 and IL-33 levels were measured before treatment, day 7 and day 14 of treatment. Results There was no significant difference in CXCL16 and IL-33 between the two groups of patients before treatment (P>0.05). The levels of IL-33 and CXCL16 were significantly lower on day 7 and 14 of treatment than before treatment (P<0.05). The levels of CXCL16 and IL-33 in berberine group were lower than those in control group (P<0.05) on day 7 and 14 of treatment (P<0.05). Conclusion Berberine plays an important role in regulating the levels of CXCL16 and IL-33 in patients with acute cerebral infarction and can improve their prognosis. Therefore, berberine hydrochloride can be added to patients with acute cerebral infarction in clinical practice.

Objective: To investigate the regulating effects of berberine on serum macrophage migration inhibition factor (MIF) and monocytes ratio (MONO%) level of acute ischemic stroke (AIS) patients. Methods: 120 AIS patients were randomly divided into routine treatment group and berberine group with 60 patients in each group. The patients in routine treatment group were given routine treatment; While the patients in berberine group were also given berberine (0.3g, tid) on basis of routine treatment. The serum MIF and MONO% level of patients were respectively detected on the 1^st and 14^th day in hospital. Results: There was no statistically significant difference about serum MIF and MONO% level of patients on the 1^st day in hospital between routine treatment group and berberine group (P>0.05). The serum MIF and MONO% level of patients in 2 group on the 14^th day were obviously lower than the 1^st day (P<0.05); Moreover, the serum MIF and MONO% level of patients in berberine group on the 14^th day were obviously lower than routine treatment group on the 14^th day(P<0.05). Conclusions: Berberine can obviously decrease the serum MIF and MONO% level of AIS patients, and inhibit inflammatory response.