Objective To study the value of allograft inflammatory factor 1(AIF-1), interleukin-6(IL-6) and vascular endothelial growth factor(VEGF) in the diagnosis and prognosis assessment of non-small cell lung cancer(NSCLC). Methods A total of 183 NSCLC patients and 120 healthy subjects were selected.and divided into NSCLC group and control group The expression of serum AIF-1, IL-6 and VEGF were compared between the two groups. The relationship between them and tumor markers such as CEA, SCCA, CYFRA21-1 and clinicopathological features of NSCLC was analyzed. ROC curve was employed to analyze the diagnostic value of the three factors in NSCLC. The relationship between serum AIF-1, IL-6, VEGF and survival was analyzed. Results The serum levels of AIF-1, IL-6 and VEGF in NSCLC patients were higher than those in healthy controls (P<0.05), was positively correlated with CEA, SCCA and CYFRA21-1 (P<0.05). The three factors were related to lymph node metastasis, distant metastasis, tumor differentiation and TNM stage (P<0.05), IL-6 was also associated with cancer tissue size(P<0.05). ROC curve analysis showed that the sensitivity, specificity, area under the curve(AUC) and 95% CI of the three combined detection were 0.88, 0.78, 0.88, 0.84-0.92, respectively, which were better than those of single index. Survival analysis showed that the overall survival rate of NSCLC patients with high expression of AIF-1 and IL-6 was significantly lower than that with low expression of AIF-1 and IL-6 (P<0.05). Conclusion AIF-1, IL-6 and VEGF are involved in the occurrence and development of NSCLC, which are helpful for the clinical diagnosis and prognosis evaluation of NSCLC.

Objective To investigate the observation on the curative effect of orthodontic forced eruption on children with embedded anterior maxillary teeth. Methods 100 children with embedded anterior maxillary teeth in the hospital from January 2014 to January 2017 were divided into control group and observation group by random number table, with 50 cases in each group. Control group underwent conventional eruption operation, and observation group was treated with eruption operation and orthodontic correction. The dental function, rate of dentition disorder, rate of pulp necrosis and satisfaction were compared between two groups. Results After treatment, the scores of swallowing function(t=4.119,P=0.000), masticatory function(t=4.897,P=0.000) and language function（t=5.828,P=0.000) in observation group were higher than those in control group, and the differences were statistically significant. After treatment, the rate of dentition disorder and rate of pulp necrosis in observation group [2.00% (1/50), 4.00% (2/50)] were lower than those in control group [16.00% (8/50), 18.00% (9/50)], and the differences were statistically significant (P<0.05). After treatment, the satisfaction of observation group [96.00% (48/50)] was higher than that of control group [80.00% (40/50)], and the difference was statistically significant (P<0.05). Conclusion Orthodontic correction in adjuvant treatment of children with embedded anterior maxillary teeth can decrease the rates of dentition disorder and pulp necrosis, improve dental function and satisfaction.