Objective To investigate the value of combined detection of carboxylpeptidyme X-M14 family member 1 (CPXM1), laminin subunit β3 (LAMβ3) and homeogenin-like protein 2 (FMNL2) in predicting postoperative recurrence in gastric cancer patients. Methods A total of 107 patients with gastric cancer admitted to the Fifth People's Hospital of Jiaozuo from January 2021 to April 2023 were selected as research objects, patients were divided into a recurrence group (n=24) and a non-recurrence group (n=83) according to their recurrence within 1 year after surgery. And different pathological features and cancer tissue levels of CPXM1, LAMβ3 and FMNL2 were compared between the two groups and their correlation was analyzed, the influencing factors of the gastric cancer patients' postoperative recurrence and their predictive value of the patients' postoperative recurrence were analyzed. Results In the recurrent group, the proportions of T3~T4 depth of invasion, poorly differentiated tumors, and lymph node metastasis, as well as the levels of LAMβ3 mRNA and FMNL2 mRNA in cancer tissues, were all higher than those in the non-recurrent group. Meanwhile, the level of CPXM1 mRNA was lower than that in the non-recurrent group (P<0.05). The level of CPXM1 mRNA in cancer tissues was negatively correlated with TNM staging, lymph node metastasis, and depth of invasion, and positively correlated with the degree of differentiation. Both LAMβ3 and FMNL2 in cancer tissues were positively correlated with TNM staging, lymph node metastasis, and depth of invasion, and negatively correlated with the degree of differentiation (P<0.05). TNM stage III, lymph node metastasis, depth of invasion, LAMβ3, and FMNL2 in cancer tissues were risk factors for postoperative recurrence in patients, while the degree of differentiation and CPXM1 mRNA in cancer tissues were protective factors (P<0.05). The combined CPXM1, LAMβ3 and FMNL2 levels predicted postoperative recurrence of patients with AUC of 0.811, which was higher than that detected by each index alone (P<0.05). Conclusion The changes of CPXM1, LAMβ3 and FMNL2 levels in cancer tissue can provide reference data for the prediction of postoperative recurrence of gastric cancer, and the combined detection has higher clinical application value.

Objective To analyze the effect of multidisciplinary cooperation combined with integrated system management model on blood glucose management of inpatients during perioperative period. Methods 180 perioperative hyperglycemia patients were selected from the income of Huizhou Central People's Hospital from January 2017 to June 2020. The random number table method was divided into 60 cases in the study group and 120 cases in the control group. efficacy indicators (FBG, 2hPBG, HbA1c, blood glucose up-to-date and up-to-date, insulin dosage, wound healing grade and days, average length of hospitalization), safety indicators (blood glucose fluctuations, hypoglycemia and incidence of complications), and health economic effects (patient satisfaction, average blood glucose control, and hospitalization costs) were compared between the two groups. Results Compared with the control group, the FBG, 2hPBG, HbA1c of the study group was lower, the blood glucose was lower, but the rate of blood glucose reached the standard was higher, the total insulin dosage and daily average dose were lower, the wound healing time and average hospitalization days were shorter, and the surgical incision healing was significantly better(P<0.05). Although there was no significant difference in the incidence of hypoglycemia between the two groups (P>0.05), the fluctuation of daytime and intraday blood glucose fluctuation and postoperative complications in the study group was smaller than that in the control group(P<0.05). In the control group, the study group scored higher in terms of medical satisfaction. Although the average blood sugar management fee was significantly higher, the hospitalization fee was significantly lower, and the difference was statistically significant (P<0.05). Conclusion The multidisciplinary and integrated system management model has good effect on the blood glucose management of perioperative inpatients, which is worthy of clinical application.