Objective: To compare the clinical effects of laparoscopic surgery, transvaginal operation and open surgery for ovarian tumor. Methods: 180 cases of benign ovarian tumor patients were divided into laparoscopic surgery group (n=70), transvaginal operation group (n=54) and open surgery group (n=56), and the patients in each group were treated with corresponding surgery. The operation time, hospital stays, first exhaust time, amount of bleeding and utilization rate of analgesic pump of patients in 3 groups were compared. The patients were followed up 3 months after operation and recorded satisfaction, cure rate, menstruation and complications of patients. Results: There had no statistical significance about operation time, cure rate and ratio of menstrual rules of 3 groups (P>0.05). There had no statistical significance of hospital stays, first exhaust time, amount of bleeding, utilization rate of analgesic pump, satisfaction and incidence rate of complications between laparoscopic surgery group and transvaginal operation group (P>0.05); But the satisfaction of patients in laparoscopic surgery group and transvaginal operation group was obviously higher than open surgery group, and other indexes were obviously lower (P<0.05). Conclusions: Treating ovarian tumor with laparoscopic surgery and transvaginal operation has the advantages of little injury, fewer complications and fast recovery. But clinical doctors should grasp the indications and contraindications strictly to decrease suffering, cost and complications.