关键词: 变应性鼻炎, Tim-1, CDCA5, PTX3, 疾病活动度

Abstract: Objective To detect the expressions of serum T-cell immunoglobulin domain mucin domain protein-1 (Tim-1), cell division cycle-related protein 5 (CDCA5), and pentoxin-3 (PTX3) in patients with allergic rhinitis, and to analyze their relationship with disease activity. Methods A total of 73 patients with allergic rhinitis admitted to the Affiliated Hospital of Putian University from August 2022 to August 2024 were selected as the research subjects and formed the study group. According to the classification criteria of disease activity, 73 patients were further subdivided into 24 mild cases, 29 moderate cases and 20 severe cases. Another 58 healthy individuals undergoing physical examinations were selected as the control group. The levels of serum Tim-1, CDCA5 and PTX3 in each group of patients were detected, their correlations with disease activity were analyzed, and the diagnostic value of combined detection of Tim-1, CDCA5 and PTX3 for allergic rhinitis was evaluated through receiver operating characteristic curve (ROC) analysis. Results Compared with the control group, the levels of serum Tim-1, CDCA5 and PTX3 in the study group increased (P<0.05). Compared with mild patients, the number of cases of allergic conjunctivitis, VAS score, SFAR score, specific immunoglobulin E (IgE), Tim-1, CDCA5, and PTX3 levels in moderate and severe patients were increased, and those in severe patients were higher than those in moderate patients (P<0.05). Correlation analysis showed that the levels of Tim-1, CDCA5 and PTX3 were positively correlated with disease activity (P<0.05). Multivariate Logistic regression analysis showed that allergic conjunctivitis, VAS score, SFAR score, IgE, Tim-1, CDCA5, and PTX3 were risk factors affecting the disease activity of patients with allergic rhinitis. ROC analysis showed that the combined detection of Tim-1, CDCA5 and PTX3 had a relatively high diagnostic value for allergic rhinitis (P<0.05). Conclusion With the increase of the severity of the disease, the levels of Tim-1, CDCA5 and PTX3 in the serum of patients with allergic rhinitis gradually increase. The combined detection of the expressions of Tim-1, CDCA5 and PTX3 can be used for the diagnosis of allergic rhinitis.

Key words: allergic rhinitis, Tim-1, CDCA5, PTX3, disease activity